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Category: Subgroup Identification

No. 15: Subgroups, Multiplicity and Bayes – A Case Study

Alzheimer's Disease has had many failures, and various companies have had mixed results. Bayesian approaches can bring clarity to the inference and primary question: "Does this treatment work?"

Steve Ruberg Bayesian Thinking, Case Studies, Subgroup Identification Leave a comment January 15, 2020March 30, 2020 10 Minutes

No. 10 – Always do Subgroup IDENTIFICATION

You may have heard, “Always do subgroup analysis, but never believe them.” Don't believe this.

Steve Ruberg Bayesian Thinking, Case Studies, Subgroup Identification Leave a comment September 30, 2019 12 Minutes

No. 9: Case Study – Genetic Subgroups and CV Disease

The over-reliance on p-values can lead to misinterpretation of data and a $150 million bet on a subgroup with scant evidence.

Steve Ruberg Bayesian Thinking, Case Studies, Subgroup Identification Leave a comment September 10, 2019January 7, 2020 10 Minutes

No. 8: Let’s Get Real – Bayes and Biomarkers

How do we know when an observed effect is real or spurious?

Steve Ruberg Bayesian Thinking, Subgroup Identification 3 Comments September 1, 2019September 8, 2019 10 Minutes
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Stephen Ruberg, PhD

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