A promising treatment for Covid-19 comes from a most unusual source - an anti-depressant treatment. Is the evidence compelling? What should we believe?
Category: Case Studies
Blog 19: We Won’t Get Fooled Again, Again
Many clinician researchers are attempting to "repurpose" old treatments for COVID-19. How shold we evaluate purported positive findings in a small, but rigorous, clinical trial?
No. 16: Beware Caesar – Alcohol Consumption and Alzheimer’s Disease
Published research from respectable journals and reported by renowned press outlets can be very misleading and of questionable importance. But it helps keep funding for the researchers and readership for the news media.
No. 15: Subgroups, Multiplicity and Bayes – A Case Study
Alzheimer's Disease has had many failures, and various companies have had mixed results. Bayesian approaches can bring clarity to the inference and primary question: "Does this treatment work?"
No. 13: Unconsciously Biased and Consciously Unbiased
Implicit models in the back of our minds can creep into explicit models creating biased predictions that have societal implications.
No. 10 – Always do Subgroup IDENTIFICATION
You may have heard, “Always do subgroup analysis, but never believe them.” Don't believe this.
No. 9: Case Study – Genetic Subgroups and CV Disease
The over-reliance on p-values can lead to misinterpretation of data and a $150 million bet on a subgroup with scant evidence.
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